Michael Zagari

Targeted Radionuclide Therapy (TRT): The Next Generation of Cancer Treatment

What is Targeted Radionuclide Therapy (TRT)?

Targeted Radionuclide Therapy (TRT) represents a paradigm shift in the field of oncology. This innovative form of treatment utilizes radioactive isotopes attached to molecules specifically designed to target and bind to cancer cells. Once connected, the radioactive substance delivers a lethal dose of radiation to the cancer cells, causing them to die or stop multiplying, while sparing nearby healthy cells.

Image + Source of Data: ITM

The radioisotopes used in TRT are chosen for their specific properties, such as the type and energy of the radiation they emit, their half-life (how long they remain active), and how they are metabolized and eliminated from the body.

Benefits of TRT

TRT offers several significant benefits over traditional cancer treatment methods like radiation and chemotherapy:

  1. Targeted Treatment: TRT targets only the cancer cells, reducing the impact on healthy cells. This specificity leads to fewer side effects compared to traditional therapies.
  2. Systemic Therapy: Unlike localized radiation therapies, TRT can treat cancer cells throughout the body, making it ideal for treating metastatic cancers (cancers that have spread to other parts of the body).
  3. Personalized Medicine: TRT can be tailored to individual patients, taking into account the type and stage of cancer, and the patient’s overall health status.
  4. Palliative Care: In many cases, TRT can effectively alleviate the symptoms associated with advanced cancers, improving quality of life.

TRT as a Better Alternative to Radiation and Chemotherapies

While radiation and chemotherapies have been instrumental in cancer treatment, they often come with severe side effects due to their non-selective nature. Here’s how TRT improves upon these traditional methods:

  1. Less Damage to Healthy Cells: Radiation and chemotherapy often affect both cancerous and healthy cells, leading to side effects like nausea, fatigue, and hair loss. As TRT is highly targeted, it spares healthy cells, minimizing these adverse reactions.
  2. Effective for Metastatic Cancers: Traditional treatments can struggle to effectively manage cancers that have spread throughout the body. TRT, however, delivers therapy systemically, treating cancer cells wherever they may be.
  3. Lower Toxicity: The targeted delivery of radiation in TRT results in a lower overall dose to the body compared to traditional external beam radiation, reducing the risk of long-term complications.
  4. Improving Quality of Life: By targeting cancer cells more precisely and causing fewer side effects, TRT can significantly enhance patients’ quality of life during treatment.

TRT represents an exciting development in the field of oncology, offering a new hope for cancer patients. As research and development continue, we can expect even more advanced and effective versions of this innovative treatment in the future.

Confidential discussions for individuals, couples, Trusts or family asset interests. We’re available to meet virtually or in-person.

We are located at 3100 boulevard de la Côte-Vertu, Suite 505, Saint-Laurent, Quebec H4R 2J8

To schedule your consultation or request client meeting, please call 514-419-5429


Nothing on the website shall be construed as an offer to buy or a solicitation of an offer to buy any services or products. Commissions, trailing commissions, management fees and expenses may be associated with investments. Products are not guaranteed, their values change frequently, and past performance may not be repeated. Mandeville Private Client Inc. is a member of the Investment Industry Regulatory Organization of Canada and a member of the Canadian Investor Protection Fund.

This publication contains the opinion of the writer. The information contained herein was obtained from sources believed to be reliable, but no representation or warranty, express or implied, is made by the writer, Mandeville, or any other person as to its accuracy, completeness, or correctness. This publication is not an offer to sell or a solicitation of an offer to buy any securities. The information in this publication is intended for informational purposes only and is not intended to constitute investment, financial, legal, tax or accounting advice.

Personal Pension Planning

We can provide advice on your company and government pension options.

In this case study, Mr. Client’s pension would represent over 50% of his total retirement income, selecting the right option was important. It was also irrevocable.

Tax Loss Harvesting

Tax Preparation is not Tax Planning.

In this case study, you will learn what ongoing and personalized advice looks like in the form of tax planning.

Diversification or Concentration

Have you ever heard the expression, “don’t put all your eggs in one basket”?

Could diversifying your portfolio work against you? In this case study, you will learn the difference between diversification or investing in only a few high-quality companies.